Vitamin C inhibits the formation of cancerous compounds in the digestive tract
Vitamin C can reduce the formation of potentially carcinogenic nitrosation products from nitrates and nitrites in the diet. This is shown by a mathematical model study by the University of Waterloo, which simulates the complex chemical interactions in the human digestive system for the first time.
In recent decades, the intake of nitrates and nitrites through the diet – especially through cured meat products and nitrate-contaminated fruit and vegetables – has increased significantly. These compounds can be converted in the stomach by nitrosation into substances that are associated with an increased risk of cancer.
The researchers led by first author Dr. Gordon McNicol developed a mathematical model that includes salivary glands, stomach, small intestine and blood plasma. The simulations showed that the simultaneous intake of vitamin C – for example through leafy vegetables such as spinach, which contains both nitrate and vitamin C – can significantly reduce the formation of these harmful compounds. Taking vitamin C supplements after meals could also have a moderate protective effect.
“Our work suggests that the presence of vitamin C in the diet may explain the previously conflicting results of previous studies on cancer risk from nitrates and nitrites,” McNicol said.
The study identifies key influencing factors such as nitrite exposure, antioxidant intake, meal timing, stomach conditions and the oral microbiota. “This model provides a mechanistic basis for more targeted clinical and laboratory studies,” added senior author Prof. Dr. Anita Layton.
The results are published in the Journal of Theoretical Biology. The researchers hope that they will support future dietary recommendations and intervention studies.
Original Paper:
Editor: X-Press Journalistenbüro GbR
Gender Notice. The personal designations used in this text always refer equally to female, male and diverse persons. Double/triple naming and gendered designations are used for better readability ected.
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