Researchers at the University Hospital of Cologne and the German Center for Infection Research (DZIF), together with a Belgian industrial partner, are developing an antibody-based rapid test for vancomycin-resistant Enterococcus faecium (VRE). The test is intended to reliably detect both important resistance mechanisms VanA and VanB and thus close a weakness in previous diagnostics.

Vancomycin-resistant enterococci are among the most dangerous hospital germs. They cause infections that are difficult to treat in immunocompromised patients. While the VanA resistance mechanism is usually well detected in routine tests, the VanB mechanism often escapes detection. This can lead to ineffective therapies and further spread of the pathogen.

The new rapid test is based on specific antibodies that directly detect the expression of resistance enzymes. A prototype is currently being evaluated with clinical isolates and in an in-vitro intestinal model from the University of Bonn. It will then be brought to market maturity together with the industrial partner. A clinical study is also being conducted to test how well the test can be integrated into the routine operation of a university diagnostic laboratory.

The aim is to provide an easy-to-use test that makes the diagnosis of VRE safer, faster and more cost-effective. The team led by Dr. Alexander Klimka and Dr. Paul Higgins from the Institute of Medical Microbiology, Immunology and Hygiene at the University Hospital of Cologne can draw on successful previous experience: Together with the same Belgian partner, they have already brought two rapid tests for the detection of carbapenemase-resistant Acinetobacter baumannii to market maturity.

The development is intended to help improve the treatment of VRE infections and to contain the spread of these problem germs in hospitals.

Editor: X-Press Journalistenbüro GbR

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