New Cochrane Review Shows Potential Benefits of HPV Vaccination After Conization
A recently published Cochrane Review, led by researchers at the University Medical Center Freiburg, suggests that HPV vaccination could also be useful in women who have already had conization. Cervical cancer, caused by high-risk HPV types such as 16 and 18, is a common gynecological disease in Germany. The study investigated whether the vaccination protects women from renewed cell changes after surgical removal of precancerous lesions (CIN2+).
The analysis is based on 13 studies with over 21,000 participants, including two randomized controlled trials (RCTs). Results show that vaccinated women are less likely to develop CIN2+ changes within two to three years (0.6–1.5%) compared to unvaccinated women (2.3%). Women after conization in particular are considered a risk group for renewed HPV-related changes. Nevertheless, the review classifies the quality of evidence as low to very low, as there are risks of bias in the RCTs and the optimal time for vaccination remains unclear.
There is a lack of meaningful data on other questions such as protection against new infections, CIN3+ or cancer itself. Evidence on side effects is also limited; mild reactions at the injection site occurred in 92% and severe allergic reactions in 1%. The review calls for further RCTs, for example from Imperial College London, to improve the evidence. Some doctors already recommend vaccination, and some health insurance companies cover the costs.
Original Paper:
Human papillomavirus (HPV) vaccination in women with conisation – Kapp, P – 2025 | Cochrane Library
Editor: X-Press Journalistenbüro GbR
Gender Notice. The personal designations used in this text always refer equally to female, male and diverse persons. Double/triple naming and gendered designations are used for better readability. ected.
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