Cell density refers to the number of cells in a certain amount of a sample, such as blood, urine or other body fluids, measured in cells per microliter (μL) or per cubic millimeter (mm³). In blood, these are mainly red blood cells, white blood cells and platelets. This measurement is a cornerstone of laboratory medicine to monitor health and diagnose diseases.

Why is it important?

Cell density is crucial for recognizing various diseases:

• Low red blood cell counts may indicate anemia, while high counts may indicate dehydration or polycythemia.
• An elevated white blood cell count may indicate infection, inflammation or leukemia, while low levels may indicate suppression of the immune system.
• A low platelet count can increase the risk of bleeding, while too many can be associated with thrombosis.
  The cell density in urine or cerebrospinal fluid (LCS) can also reveal inflammation or infection.

How is it measured in Germany?

Modern, automated systems are used in German laboratories, such as:

• Electrical impedance method: Cells pass through a nozzle and the change in electrical resistance counts and measures the cells.
• Flow cytometry (flow cytometry): Lasers measure the optical properties of the cells in order to distinguish and count them.
• Manual counting: With a counting chamber, such as the Neubauer chamber, for urine or LCS, if necessary.
  Laboratories follow the guidelines of the German Medical Association(Rili-BÄK) for quality assurance to ensure accurate results. Commonly used devices are from manufacturers such as Siemens, Beckman Coulter or Sysmex, which are standard worldwide.

Matching:

New procedure improves treatment of leukemia and lung cancer – MedLabPortal

Blood cancer in children: New antibody can kill leukemia cells – MedLabPortal

Editorial office: X-Press Journalistenbüro GbR

Gender note. The personal designations used in this text always refer equally to female, male and diverse persons. Double/triple references and gendered designations are avoided for the sake of better readability ected.