Kaiserslautern: Graphene massively increases the sensitivity of plasmonic biosensors
A research team at Kaiserslautern University of Applied Sciences has developed a method that significantly increases the sensitivity of plasmonic biosensors by means of a wafer-thin graphene layer. The results were published in the journal “Advanced Healthcare Materials” and were presented on the cover of the current issue.
The research group led by Prof. Dr. Alexey Tarasov combined a single layer of graphene with surface plasmon resonance (SPR) sensors. In various biological tests, graphene amplified sensor signals by up to 600 percent. This effect is significantly higher than previously known values.
The improved sensors enable highly sensitive real-time observation of interactions between biomolecules, viruses or cells. Among other things, the experiments investigated bindings between antibodies and viruses as well as between peptides and immune cells. It was also possible to distinguish different cell types from each other – a result that was not achievable with conventional sensor surfaces.
The technology opens up new perspectives for medical diagnostics, the analysis of immune reactions, the development of therapies and rapid point-of-care tests. In addition to the Kaiserslautern University of Applied Sciences, the company PROGEN Biotechnik GmbH was involved in the study.
The publication is titled “Graphene-Enhanced Plasmonic Interfaces: A General Strategy for Highly Sensitive Detection of Biomolecular Interactions”.
Original Paper:
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