Fraunhofer researchers have developed a substance that inhibits harmful bacteria in periodontitis without destroying the entire oral microbiome. The spin-off PerioTrap has launched dental care products on the market that maintain the natural balance of the oral flora. The technology addresses a widespread health problem with potentially serious consequences.

Periodontitis is one of the most common chronic diseases worldwide and affects millions of people. It is caused by an imbalance in the oral microbiome, which includes over 700 species of bacteria. Only a few species, such as Porphyromonas gingivalis, cause the condition by sticking to the plaque at the gum line and triggering inflammation. Initial gingivitis can lead to chronic periodontitis, in which the gums recede and teeth loosen. The bacteria can promote systemic diseases via the bloodstream, including diabetes, rheumatism, arthritis, cardiovascular problems, chronic inflammatory bowel disease and Alzheimer’s disease.

Traditional oral care products, such as rinses with alcohol or chlorhexidine, kill all germs, including beneficial ones. After treatment, pathogenic bacteria build up faster because they grow better on inflamed tissue. The microbiome goes into dysbiosis, and the disease returns. Periodontitis is not only a local problem, but affects general health and causes high treatment costs.

Guanidinoethylbenzylamino Imidazopyridine Acetate comes from an EU project with international partners. Researchers at the Fraunhofer Institute for Cell Therapy and Immunology IZI in Halle identified it as a selective inhibitor of harmful pathogens. It does not kill the bacteria, but blocks their growth so that they do not have toxic effects. Healthy germs can occupy niches and stabilize the microbiome.

The spin-off PerioTrap Pharmaceuticals, founded in Halle in 2018, developed the technology into products. In cooperation with Fraunhofer IZI and the Fraunhofer Institute for Microstructure of Materials and Systems IMWS, a microbiome toothpaste was created. This contains cleaning agents and fluoride against tooth decay and serves to prevent periodontitis.

According to the developers, the substance works gently and in harmony with the oral flora. It inhibits pathogens such as Porphyromonas gingivalis, leaving beneficial bacteria untouched and preventing dysbiosis. In contrast to broad-spectrum remedies, it promotes a stable balance. The pasta is non-toxic, does not absorb and does not cause discoloration.

Tests according to Good Laboratory Practice (GLP) confirmed efficacy and tolerability. The Fraunhofer IZI tested biochemical and structural biology aspects, the IMWS material science properties. Scanning electron microscopy and chemical analyses showed positive effects on teeth and gums.

The PerioTrap toothpaste is on the market. A care gel for dental practices, applied after professional cleaning, blocks pathogens and stabilizes the flora. Other products such as mouthwash are in development. The technology is also suitable for animal care: periodontitis in dogs and cats has similar causes, products for pets are on the agenda.

Editor: X-Press Journalistenbüro GbR

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