Selpercatinib shows survival benefits in medullary thyroid carcinoma
A re-evaluation of selpercatinib as a first-line treatment for advanced RET-mutated medullary thyroid carcinoma has shown a significant additional benefit compared to the comparator therapies vandetanib and cabozantinib. The Institute for Quality and Efficiency in...
Neutrophils: New therapeutic approach against cancer discovered
Researchers at the Faculty of Medicine at the University of Duisburg-Essen have developed a promising approach to fighting cancer. Under the direction of Prof. Dr. Jadwiga Jablonska, the targeted blockade of the STAT3 signaling pathway in neutrophil granulocytes was...
Pregnancy: Saliva samples reveal the impact of environmental chemicals on health
A groundbreaking study, published on July 22, 2025 in the International Journal of Oral Science (DOI: 10.1038/s41368-025-00390-8), shows how saliva samples can provide new insights into the effects of everyday chemical exposures on the health of pregnant women....
Nationwide testing of the medical staffing system started
With the Medical Personnel Assessment System (ÄPS-BÄK), the German Medical Association (BÄK) has developed an instrument to precisely determine the actual need for medical staff in hospitals. After a successful pilot phase in ten hospitals, nationwide testing is now...
New ESC guidelines on valvular heart disease published
On 29 August 2025, the updated European guidelines for the treatment of valvular heart disease were presented at the ESC Congress in Madrid. The guidelines, jointly developed by the European Society of Cardiology (ESC) and the European Society of Cardiac and Thoracic...
Digitoxin shows clear benefits in heart failure
A large-scale study by the Hannover Medical School (MHH) proves the efficacy and safety of digitoxin in advanced heart failure (HFrEF). The DIGIT-HF study, which was conducted over ten years with more than 1,200 participants, shows that cardiac glycoside significantly...
New method reveals lipid transport in cells
A research team from Dresden and Prague has developed a groundbreaking imaging method that makes it possible to track individual lipids in cells for the first time. This allowed the scientists to uncover the primary mechanism of lipid transport within cells, which is...
Protein controls pause state of egg cells
Researchers at the Universities of Konstanz and Göttingen have discovered a protein that controls the long-term pause in egg cell maturation in vertebrates. The study, published in Nature Communications, sheds light on how the protein 4E-T interrupts egg maturation...
Nicotine pouches endanger consuming children with neurotoxin
The Children's Health Foundation is sounding the alarm: Nicotine pouches, small packets with highly concentrated nicotine, are gaining popularity among children and adolescents in Germany. Despite their illegal sale, they are easily accessible and pose significant...
New study reveals mechanisms of brain fold formation
In a study, researchers at the Max Planck Institute for Biological Intelligence have gained new insights into the formation of folds in the cerebral cortex, which occur in humans and some animal species such as primates, whales, dolphins and pigs. These folds,...
