DFG funds new Research Training Group on Tumor Organoids in Ulm

by | Dec 18, 2025 | Health, Research

From spring 2026, 20 doctoral students in the life sciences and ten physicians will conduct research on realistic models of solid tumors in the new Org-BOOST Research Training Group at Ulm University. The aim is to better predict disease progression and therapeutic effects for personalized cancer medicine.

The German Research Foundation is funding the programme with almost nine million euros over five years. The focus is on patient-derived organoids as mini-tumors, combined with immune, connective tissue and vascular cells to form assembloids to simulate tumor microenvironments.

Microscopic image of a coculture of patient-derived bladder organoids and associated cancer-associated fibroblasts. The immunofluorescence images show tumor organoids of the urinary bladder (red) embedded in a fibroblastic tumor environment | Source: Dr. M.Melzer, Prof. A. Kleger | Copyright: Dr. M.Melzer, Prof. A. Kleger / Uni Ulm
Microscopic image of a coculture of patient-derived bladder organoids and associated cancer-associated fibroblasts. The immunofluorescence images show tumor organoids of the urinary bladder (red) embedded in a fibroblastic tumor environment | Source: Dr. M.Melzer, Prof. A. Kleger | Copyright: Dr. M.Melzer, Prof. A. Kleger / Uni Ulm

Ten networked projects deal with tumors of the pancreas, urinary bladder, intestine, breast and blood. The Core Facility Organoids serves as a biobank for samples, complemented by machine learning and automation.

The Research Training Group is integrated into the International Graduate School in Molecular Medicine Ulm and cooperates with the 3R Center and the Comprehensive Cancer Center Ulm to reduce animal experiments.


Editor: X-Press Journalistenbüro GbR

Gender Notice. The personal designations used in this text always refer equally to female, male and diverse persons. Double/triple naming and gendered designations are used for better readability. ected.

X
Ich bin Invi, wie kann ich dir helfen?