Greifswald method accelerates drug development
Researchers at the University Medical Center Greifswald have developed an innovative method that makes the examination of renal corpuscles (glomeruli) much faster and more precise. The method, called “Glomage”, combines rapid isolation of the tiny structures with 3D microscopy and AI-supported image analysis.
The team led by Prof. Nicole Endlich from the Institute of Anatomy and Cell Biology was thus able to create complete three-dimensional models of the glomeruli, which are only 30–40 micrometers in size, for the first time. The new technique allows an accurate count of the vital podocytes (foot cells) responsible for blood filtration. Their loss inevitably leads to chronic kidney disease and even kidney failure.
Until now, such analyses were either extremely time-consuming (up to three weeks) or only inaccurate. With Glomage, the process is shortened to two to three days. The method was first developed on zebrafish larvae and successfully transferred to mouse kidneys. In cooperation with the University of Zurich, image analysis has been further refined by artificial intelligence.
The researchers also used the new technique to test a promising drug that could prevent or stop the loss of podocytes. In addition, it was possible to obtain high-purity RNA from the isolated glomeruli in order to investigate molecular processes in the cells in detail.
The study was published in the journal Advanced Science .
Original Paper:
Editor: X-Press Journalistenbüro GbR
Gender Notice. The personal designations used in this text always refer equally to female, male and diverse persons. Double/triple naming and gendered designations are used for better readability ected.
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