Li-Fraumeni syndrome: Study shows role of the immune system in cancer risk
Li-Fraumeni syndrome greatly increases the risk of cancer. This is the conclusion of an international study that shows that the immune system influences both the age and the form of cancer onset. This opens up approaches for personalized care. The results were published in the journal Lancet.
The syndrome is caused by mutations in the TP53 gene, which normally protects against cancer. Almost all those affected develop cancer at least once. However, the risk of cancer varies within families. Researchers from Université Grenoble Alpes, Université de Rouen Normandie and Hannover Medical School investigated reasons for this.
The immune system recognizes altered TP53 proteins in some mutations. These variants lead to later cancer onset and rarer diseases of bone or soft tissue sarcomas. The risk decreases overall because the immune system recognizes abnormal protein as a fragment.
The study has no direct impact on treatment. However, it suggests personalized surveillance and prevention, based on TP53 variant and immune status. This could also apply to other hereditary cancers.
Original Paper:
Editor: X-Press Journalistenbüro GbR
Gender Notice. The personal designations used in this text always refer equally to female, male and diverse persons. Double/triple naming and gendered designations are used for better readability. ected.
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