A groundbreaking study from Leipzig shows that short-term weight loss through lifestyle changes can have long-term positive effects on the cardiovascular system, even if the weight gains again later. Researchers at Leipzig University Hospital investigated changes in the blood plasma of men with metabolic syndrome.

The study involved 58 non-smoking men aged 45 to 55 who had all the characteristics of metabolic syndrome, including obesity, high blood lipid levels and elevated blood pressure. Over a period of six months, they completed a supervised program with nutritional advice and exercise recommendations, which was monitored by telemedicine. Of the 37 participants who were followed up after five years, most had initially lost at least ten percent of their initial weight, but only a few maintained this loss.

The average body mass index dropped from 33 to below 29 during the intervention, but rose again to over 32 after five years. Despite this regression, changes in blood plasma-based proteins associated with cardiovascular disease remained. The analysis with a special panel revealed persistently reduced levels of proteins such as leptin and interleukin-18, which are associated with inflammation, insulin resistance and atherosclerosis.

The results suggest that temporary weight loss may provide lasting metabolic benefits, regardless of long-term weight development.

Important details can be seen as posters at the DKLM 2025 in Leipzig. Interested media can receive the poster in advance in compliance with the strict embargo period of 23.10.2025 / 00:01 and presentation of a valid press card. To do so, send us your enquiry including a copy of your press card to: redaktion@medlabportal.de

The German Congress of Laboratory Medicine (DKLM) 2025 promises exciting insights into the interface between science and clinical practice. Under the motto “Science for Precision Medicine”, the German Society for Clinical Chemistry and Laboratory Medicine (DGKL) and the Umbrella Association for Technologists and Analysts in Medicine Germany (DVTA) invite experts from research, clinics and industry to meet on October 23 and 24 at the Congress Center Leipzig (CCL). The two-day event is aimed at laboratory physicians, biomedical analysts and decision-makers to discuss current advances in diagnostics and strengthen networks. The ceremonial opening of the congress will take place on 22 October with the presentation of the MedLabAwards in the Salles de Pologne.

Editor: X-Press Journalistenbüro GbR

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