RSV vaccines: Safe and effective protection for vulnerable groups
An international review of 14 clinical trials involving over 100,000 participants confirms that respiratory syncytial virus (RSV) vaccines are safe and effective, especially for older adults and young children who are at high risk of severe disease. RSV often causes coughs and colds, but it can also cause life-threatening lung infections such as pneumonia.
Besonders gefährdet sind Kinder unter zwei Monaten sowie ältere Erwachsene. Die Studien, die in verschiedenen Ländern und auf allen Kontinenten durchgeführt wurden, umfassten ältere Erwachsene, Schwangere, Frauen im gebärfähigen Alter und Kinder. Die Ergebnisse zeigen, dass RSV-Präfusionsimpfstoffe bei älteren Erwachsenen RSV-bedingte Erkrankungen der unteren Atemwege wie Lungenentzündung und Bronchitis um 77 Prozent und akute Atemwegserkrankungen wie Erkältungen um 67 Prozent reduzieren. Die Impfung von Schwangeren mit einem Impfstoff auf Basis des RSV-F-Proteins senkte das Risiko, dass ihre Kinder wegen RSV-bedingter Atemwegserkrankungen ärztlich behandelt werden mussten, um 54 Prozent, das Risiko schwerer Erkrankungen um 74 Prozent und das Risiko einer Krankenhauseinweisung um 54 Prozent.
The review found that there are little to no differences in serious side effects between vaccinated and non-vaccinated people across all age groups. The data come exclusively from randomized clinical trials, as no real-world findings were available at the time of publication. Ongoing studies under real conditions are intended to further deepen knowledge about the safety and efficacy of the vaccines. The European Centre for Disease Prevention and Control (ECDC) plans to publish an updated analysis with new data in the coming weeks, followed by two more analyses on the efficacy and safety of the RSV vaccines.
Original Paper:
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